An exciting new partnership brings the TAMARA nanoparticle formulation system to the USA & Canada.
Microfluidics, an IDEX MPT company, is delighted to announce an exciting new partnership with Inside Therapeutics (Inside Tx), who appointed us as the sole distributor in the USA & Canada for the revolutionary TAMARA platform.
This unique plug-and-play nanoparticle formulation system is designed to meet the needs of smaller scale R&D exploration. It will sit alongside our existing high shear homogenizer portfolio and enables us to offer a wider range of solutions to our customers.
A Game-Changing, Cost-Effective R&D Solution
TAMARA stands out as the only platform that seamlessly integrates all R&D nanoparticle formulation stages into a single machine, facilitating a smooth transition from low-volume screening (200µL) up to in-vivo scale studies (30mL per batch). This eliminates the need to switch up to different models during scale-up to reach the volumes needed, significantly boosting the success rate of drug development.
TAMARA utilizes microfluidics technology to synthesize LNPs through a bottom-up, self-assembly approach. Unlike other microfluidics systems, these chips are recyclable, thanks to an advanced in-built cleaning protocol. Furthermore, these microfluidic chips integrate two mixing designs on a single reversible chip, the baffle or the herringbone mixer. This offers versatile mixing methods which are selected to align with specific research goals.
Its pioneering fluidic design eradicates head and tail losses, conserving valuable API material whilst significantly lowering operational costs. The video below demonstrates this functionality.
Improved Processing Speeds With Unmatched Repeatability
TAMARA is very easy to use, it is quick and intuitive to set up and get going, it is ideal for newcomers as well as giving the performance expected by seasoned experts. Samples can be run in under 2 minutes, allowing over 20 formulations to be done per hour, revolutionizing the efficiency of your screening processes.
Users have independent and precise control over the formulation parameters like Total Flow Rate (TFR) and Flow Rate Ratio (FRR), enabling you to tailor every aspect of the process to meet your R&D goals. The precision of this microfluidic mixing ensures the highest level of repeatability, setting a new standard in research excellence.
Users have commented that TAMARA offers “a combination of precision, scalability, and usability that sets it apart” and that they are “blown away by how user friendly, efficient and straight to the point this system is”.
A Synergistic Collaboration
The TAMARA platform is a beacon of R&D versatility, capable of synthesizing a diverse array of polymer and lipid-based nanoparticles, including RNA LNPs, Liposomes, Solid Lipid Nanoparticles (SLNs), polymeric nanoparticles, and cutting-edge next-generation nanoparticles.
Inside Therapeutics is a French based company and have stated, "Our InsideTx team is thrilled to join forces with Microfluidics from IDEX MPT as we expand our footprint in Canada & America. Following our highly successful TAMARA launch in Europe and obtaining some key installations in the U.S., including the Nobel Prize labs, we’re excited to introduce our proven microfluidic-based RNA-LNP R&D formulation platform to the world’s largest biotech market. Microfluidics' top-down expertise in nanoparticle formulation perfectly complements our bottom-up formulation approach, creating a powerful synergy to further extend our reach and promote the global adoption of RNA-LNP technology!"
As a result of adding TAMARA to the Microfluidics, IDEX MPT range of high shear homogenisers we become the only company that offers both top-down and bottom-up LNP processing methods and enables us to offer our customers the widest range of manufacturing volumes from the very smallest volume (200µL) all the way up to production scale. We can help our customers compare & contrast which is the best methodology to meet their objectives.
Anna Wynn President of IDEX MPT said, “We are thrilled to be working with the team at Inside Therapeutics and bring TAMARA to our key markets. Our commitment to helping customers solve critical problems in the biopharma sector is enriched by adding this groundbreaking R&D solution to our current portfolio. Together, we are poised to make a significant impact as we partner with our customers to bring innovative therapies to our communities."
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If you would like to know more about any of the technology on offer, please don’t hesitate to contact us. Just fill out the form and we will get in contact.
We offer testing facilities or rental of test equipment, so you can gain confidence in your decision-making.
