for Nanoencapsulation

Microfluidizer® Technology Provides a Competitive Edge

Your Challenges

Achieving high drug loading with hydrophilic and hydrophobic drugs with uniform particle size has proven to be quite difficult.

Our Experience

Let us use our collective 90 years of applications development and machine engineering experience to help drive your product to market as quickly as possible.

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How we can help

The use of Microfluidics technology can achieve reproducible, scalable particle sizes with high encapsulation rates of hydrophilic and/or hydrophobic drugs. 

Our Approach

Microfluidizer® processors are designed to be simple to use and clean with the option of conforming to cGMP requirements. 

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In detail

Nanoencapsulation

Nanoencapsulation Techniques

Nanoencapsulation techniques using nanoemulsions, liposomes and polymers are primarily used in the pharmaceutical, nutraceutical/food and cosmetic industries.

Nanoencapsulation in food, drug and other applications enables companies to achieve:

  • Time release of actives (e.g., small and large molecule drugs, pesticides/herbicides)
  • Targeted drug delivery
  • Odor/flavor masking (e.g., fish oil)
  • Protection (e.g., vitamins, DNA, tattoo ink, fish oil) 

Advantages of Microfluidizer Technology for Nanoencapsulation

Customers using Microfluidizer® processor technology for nanoencapsulation applications enjoy competitive differentiation for their products and processes:

  • Smaller particle sizes
  • Uniform particle size distribution
  • Efficient encapsulation rates
  • Effective cooling
  • Precise shear
  • Controlled mixing intensity of reactant streams
  • Ease of use, cleaning and maintenance
  • Scaleup guaranteed

Proven Drug Nanoencapsulation Results

Nanoemulsions:

Fish oil contains Omega-3 fatty acid, an essential nutrient. Encapsulating the fish oil using a nanoemulsion substantially reduces its undesirable taste and protects the oil from oxidation.

Liposomes:

In the example below, 0.1% plasmid DNA is encapsulated inside a Palmitoyl oleoyl phophatidyl choline liposome. DNA remains.

Polymers:

Microfluidizer® technology is ideally suited for applications requiring highly efficient polymer encapsulation.

Before After

 

nanoencapsulation-a

 

nanoencapsulation-b (1)

Polydispersity DNA Encapsulation in a Liposome

 

nanoencapsulation-poly

liposome-encapsulation

 

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Resources

Webinar

Yvonne Perrie - Professor, Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclude, Glasgow joins Microfluidics International Corporation to discuss her liposome research performed with the Microfluidizier

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