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APPLICATIONS

Nanoencapsulation

Microfluidizer® Technology Provides a Competitive Edge

Nanoencapsulation is nanoscale particles or droplets surrounded by a coating or wall. This encapsulation is used to enclose one or more active ingredient and is used in the pharmaceutical, nutraceutical/food and cosmetic industries.

EXPLORE:

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YOUR CHALLENGES

Uniform Particle Size

Achieving high drug loading with hydrophilic and hydrophobic drugs with uniform particle size has proven to be quite difficult.

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HOW WE CAN HELP

High Encapsulation Rates

The use of Microfluidics technology can achieve reproducible, scalable particle sizes with high encapsulation rates of hydrophilic and/or hydrophobic drugs.

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OUR APPROACH

Easy to Use and Scalable

Microfluidizer® processors are designed to be simple to use, clean and maintain. Conforming to cGMP requirements is an option for select equipment.

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OUR EXPERIENCE

Effective Solutions

Let us use our decades of application development and machine engineering experience to help drive your product to market as quickly as possible.

TECHNIQUES

Nanoencapsulation Techniques

Nanoencapsulation techniques using nanoemulsions, liposomes and polymers are primarily used in the pharmaceutical, nutraceutical/food and cosmetic industries.


Nanoencapsulation enables companies to achieve:

  • Time release of actives (e.g., small and large molecule drugs, pesticides/herbicides)
  • Targeted drug delivery
  • Odor/flavor masking (e.g., fish oil)
  • Protection (e.g., vitamins, DNA, tattoo ink, fish oil) 
ADVANTAGES

Benefits of Microfluidizer® Technology for Nanoencapsulation

Customers using Microfluidizer® technology for nanoencapsulation applications enjoy competitive differentiation for their products and processes:

  • Smaller particle sizes
  • Uniform particle size distribution
  • Efficient encapsulation rates
  • Effective cooling
  • Precise shear
  • Controlled mixing intensity of reactant streams
  • Ease of use, cleaning and maintenance
  • Scaleup guaranteed
RESULTS

Proven Drug Nanoencapsulation Results

Nanoemulsions

Fish oil contains Omega-3 fatty acid, an essential nutrient. Encapsulating the fish oil using a nanoemulsion substantially reduces its undesirable taste and protects the oil from oxidation.

Before

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After

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Polymers

Microfluidizer® technology is ideally suited for applications requiring highly efficient polymer encapsulation.

Polydispersity

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Liposomes

In the example below, 0.1% plasmid DNA is encapsulated inside a Palmitoyl oleoyl phophatidyl choline liposome. DNA remains.

DNA Encapsulation in a Liposome

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BLOG ARTICLES

Expert Advice and Information

Recommended downloads for manufacturers working in the pharmaceutical industry.

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Apr 25, 2024 7:19:09 PM

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Scalable Technology for Cosmetic Manufacturing

Apr 19, 2024 1:55:14 PM

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Results: Solvent-free Technology for Oral Bioavailability Enhancement

Jun 23, 2022 1:57:53 PM

Microfluidics' Senior Application Engineer, Chris Jaquin, recently joined Dr...

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