Applications

Nanoencapsulation

Microfluidizer® Technology Provides a Competitive Edge

Nanoencapsulation is nanoscale particles or droplets surrounded by a coating or wall. This encapsulation is used to enclose one or more active ingredient and is used in the pharmaceutical, nutraceutical/food and cosmetic industries.

EXPLORE

Technology for effective Nanoencapsulation

Nanoencapsulation

Your Challenges

Uniform Particle Size

Achieving high drug loading with hydrophilic and hydrophobic drugs with uniform particle size has proven to be quite difficult.

How We Can Help

High Encapsulation Rates

The use of Microfluidics technology can achieve reproducible, scalable particle sizes with high encapsulation rates of hydrophilic and/or hydrophobic drugs.

Our Experience

Effective Solutions

Let us use our collective 90 years of applications development and machine engineering experience to help drive your product to market as quickly as possible.

Our Approach

Easy to Use and Scaleable

Microfluidizer® processors are designed to be simple to use and clean with the option of conforming to cGMP requirements. 

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In Detail

Nanoencapsulation

Nanoencapsulation Techniques

Nanoencapsulation techniques using nanoemulsions, liposomes and polymers are primarily used in the pharmaceutical, nutraceutical/food and cosmetic industries.

Nanoencapsulation in food, drug and other applications enables companies to achieve:

  • Time release of actives (e.g., small and large molecule drugs, pesticides/herbicides)
  • Targeted drug delivery
  • Odor/flavor masking (e.g., fish oil)
  • Protection (e.g., vitamins, DNA, tattoo ink, fish oil) 

 

Advantages of Microfluidizer® Technology for Nanoencapsulation

Customers using Microfluidizer® technology for nanoencapsulation applications enjoy competitive differentiation for their products and processes:

  • Smaller particle sizes
  • Uniform particle size distribution
  • Efficient encapsulation rates
  • Effective cooling
  • Precise shear
  • Controlled mixing intensity of reactant streams
  • Ease of use, cleaning and maintenance
  • Scaleup guaranteed

Proven Drug Nanoencapsulation Results

Nanoemulsions:

Fish oil contains Omega-3 fatty acid, an essential nutrient. Encapsulating the fish oil using a nanoemulsion substantially reduces its undesirable taste and protects the oil from oxidation.

Liposomes:

In the example below, 0.1% plasmid DNA is encapsulated inside a Palmitoyl oleoyl phophatidyl choline liposome. DNA remains.

Polymers:

Microfluidizer® technology is ideally suited for applications requiring highly efficient polymer encapsulation.

Before After

 

nanoencapsulation-a

 

nanoencapsulation-b (1)

Polydispersity DNA Encapsulation in a Liposome

 

nanoencapsulation-poly

liposome-encapsulation

 

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Resources & Guides

Nanoencapsulation Resources

Recommended downloads.