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Nanoencapsulation

Microfluidizer® Technology Provides a Competitive Edge

Your Challenges

Achieving high drug loading with hydrophilic and hydrophobic drugs with uniform particle size has proven to be quite difficult.

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Let us use our collective 90 years of applications development and machine engineering experience to help drive your product to market as quickly as possible.
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How we can help

The use of Microfluidics technology can achieve reproducible, scalable particle sizes with high encapsulation rates of hydrophilic and/or hydrophobic drugs. 

Our Approach

Microfluidizer® processors are designed to be simple to use and clean with the option of conforming to cGMP requirements. 
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In detail

Nanoencapsulation

Nanoencapsulation Techniques

Nanoencapsulation techniques using nanoemulsions, liposomes and polymers are primarily used in the pharmaceutical, nutraceutical/food and cosmetic industries.

Nanoencapsulation in food, drug and other applications enables companies to achieve:

  • Time release of actives (e.g., small and large molecule drugs, pesticides/herbicides)
  • Targeted drug delivery
  • Odor/flavor masking (e.g., fish oil)
  • Protection (e.g., vitamins, DNA, tattoo ink, fish oil) 

Advantages of Microfluidizer Technology for Nanoencapsulation

Customers using Microfluidizer® processor technology for nanoencapsulation applications enjoy competitive differentiation for their products and processes:

  • Smaller particle sizes
  • Uniform particle size distribution
  • Efficient encapsulation rates
  • Effective cooling
  • Precise shear
  • Controlled mixing intensity of reactant streams
  • Ease of use, cleaning and maintenance
  • Scaleup guaranteed

Proven Drug Nanoencapsulation Results

Nanoemulsions:

Fish oil contains Omega-3 fatty acid, an essential nutrient. Encapsulating the fish oil using a nanoemulsion substantially reduces its undesirable taste and protects the oil from oxidation.

Liposomes:

In the example below, 0.1% plasmid DNA is encapsulated inside a Palmitoyl oleoyl phophatidyl choline liposome. DNA remains.

Polymers:

Microfluidizer® technology is ideally suited for applications requiring highly efficient polymer encapsulation.

Before After

 

nanoencapsulation-a

 

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Polydispersity DNA Encapsulation in a Liposome

 

nanoencapsulation-poly

 liposome-encapsulation

 

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Resources

Webinar

Yvonne Perrie - Professor, Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclude, Glasgow joins Microfluidics International Corporation to discuss her liposome research performed with the Microfluidizier

WEBINAR Listen to the webinar on formulating liposomes & the importance of vesicle size control. >click here
Liquid Nano Particle Size Reduction

Microfluidics International Corporation, the manufacturer of Microfluidizer® high shear fluid processors, is a leader in the design and production of laboratory and commercial processing equipment used in the production of micro- and nano-scale materials for pharmaceutical, biotech, chemical and diverse industries. 

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