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M700 Series Microfluidizer® ProcessorProduction scale homogenizer

Ultra High Shear Fluid Processing of manufacturing batches

Once the suitable pilot batches are achieved, scale up seamlessly to full production with one of the M700 series models. 

The M700 series processors have proven to be cost-effective in a broad range of industries. Utilizing the Microfluidizer® technology, these processors deliver the finest and most uniform distribution of submicron particle size at the highest shear rates available. Emulsions and suspensions are more stable, creating superior final products.

The M700 series machines have the same high-pressure, multi-slotted fixed-geometry Interaction ChambersTM that all the Microfluidics equipment possess.  It means that identical high shear rates are imparted to product formulations as are achieved on lab scale and pilot scale machines through scalable Interaction ChambersTM.

The M7125 and M7250 models generate up to 30,000 psi operating pressure for premium results at an affordable cost.  Flow rates of 300 to 900 L/hr are achievable with the right model.

A broad range of throughput in continuous or batch mode is possible due to the fact that the machine can process at a wide range of pressures and flows.

Download the M700 series brochure

Available For

Pharma and Biotech

cGMP Compliant badge

Pharma & Biotech options are available for production scale processing - with a range of options available to suit specific requirements.

This equipment is specifically designed to achieve cGMP standards, there are a range of models to suit the standard Biopharma needs, moving on to the Enhanced Biopharma model and on to the Aseptic Biopharmaceutical model. These options are critical when scaling up from the lab to pilot batches in typical applications such as making vaccine adjuvants and creating sterile nanoemulsions.

Basic Biopharma:

  • cGMP as specified by the American Society for Mechanical Engineers
  • Traceability – Material Certificates for all product contact parts included in an electronic Turnover Package (TOP)
  • Surface Finish – Electropolished and passivated - surface finish of < 20 Ra 
  • USP Class VI elastomers
  • Drainability – A sanitary heat exchanger, a sanitary flush pressure transducer and pitched piping are included to ensure all equipment can be drained effectively
  • CIP - clean in place

 

Enhanced Biopharma:

  • includes all of the above features plus 21 CFR Part 11 Data Acquisition
  • Industrial Personal Computer (IPC)
  • other options include - automation, conductivity sensors & mass flow meter

 

Aseptic Biopharma:

  • all of the above features plus Steam in Place (SIP) for processing in a sterile environment
  • equipment is fully automated
  • also recipes for Steam, Prime, Run & Drain

Aseptic Biopharma model:

M7250-Aseptic-Biopharma
 

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In detail

M700 Series production scale homogenizer

The M700 Series and M7125 and M7250 Models have a range of options:

Standard Features:

  • Proven to be highly reliable at operating pressures up to 30,000 psi in pilot and production environments.
  • Generates the highest shear rates of any fluid processor on the market today, which results most often in achieving desired product quality in a single pass.
  • Wear-resistant Interaction Chamber™ with fixed-geometry design ensures that the entire product stream encounters equal energy-per-unit fluid volume.
  • Highly durable intensifier pumping system is efficient at ultra-high pressures.
  • High-pressure plunger seals and check valves
  • Model M7250 unit comes standard with two synchronized intensifier pumps for increased flow rates.
  • Open isolator to prevent process fluid and hydraulic fluid contact.
  • Simple, efficient electric/hydraulic drive system
  • Coned and threaded tubing and fittings
  • In-line cleaning with no disassembly required
  • All stainless-steel construction
  • Validatable for cGMP and cGAMP applications

 

 

For the M-710 Materials Processor Model - standard features:

  • Dual synchronous intensifier pump provides reproducible, reliable results
  • Constant pressure feature is available with M710 machines operating at process pressures of 1379 bar (20,000 psi) and above
  • Wear-resistant Interaction Chamber™ technology maximizes energy-per-unit volume of product
  • Highest shear rates of all available competitive processors
  • Easy in-line cleaning and simple maintenance

The specifications of the M700 series production scale models are:

M7125 model:
  • Operating pressure of up to 40,000 psi/2755 bar
  • Flow rate @ 25 s/m- up to 7.78 L/min
  • Power - 25 HP / 460 V 3 phase

M7250 model:
  • Operating pressure of up to 40,000 psi/2755 bar
  • Flow rate @ 25 s/m- up to 15.6 L/min
  • Power - 50 HP / 460 V 3 phase

M700 details

 

Models M7125 and M7250 are recommended for:

  • Immiscible Liquid Emulsions
  • Solid-in-Liquid Suspensions
  • Submicron Particle Size Reduction
  • Deagglomeration and Dispersion

Model M710 is recommended for:

  • Stable Solid-in-Liquid Dispersions
  • Stable Microemulsions
  • Submicron Particles (Nanoparticles)
  • Deagglomeration

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Pilot scale equipment

Reduce time to market with linear scaleup from the Lab to the Production Line

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For Continuous, High Shear Fluid Processing

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Microfluidics International Corporation, the manufacturer of Microfluidizer® high shear fluid processors, is a leader in the design and production of laboratory and commercial processing equipment used in the production of micro- and nano-scale materials for pharmaceutical, biotech, chemical and diverse industries.

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