for Polymer Nanoparticles

• Delivery of a combination of various therapeutic ingredients

• Ability to include targeting moieties

• Protecting active ingredients from degradation to ensure efficacy

• Control of the release of ingredients

• Particles small enough to be sterilized through filtration

Key Formulation stages

• Aqueous phase: water + surfactant are combined

• Oil phase:  the polymeric and other hydrophobic ingredients (such as actives, contrast agents, etc.) are dissolved in the water immiscible solvent.

Processing steps

• Prepare the separate oil & aqueous phases

• Add oil to the water phase

• Mix using a rotor-stator motor to create a coarse emulsion as a stable pre-mix

• Process the pre-mix using a Microfluidizer^® high shear homogenizer - in selecting the model, consider the critical processing parameters of chamber type, processing pressure, temperature and number of passes

Particle size analysis is often used to evaluate polymer nanoparticles.

Utilizing specific analytical techniques, including dynamic light scattering, optical microscopy, and SEM or TEM, we have found that Microfluidizer^® technology is able to reduce polymer droplet size significantly after several passes.

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