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for Polymer Nanoparticles

Ideal Technology for Producing Polymer Nanoparticles

Your Challenges

To produce biodegradable nanoparticles that have the capability of including targeting moieties, combination of different therapeutic ingredients.

Our Experience

Let us use our collective 90 years of applications development and machine engineering experience to help drive your product to market as quickly as possible.
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How we can help

Microfluidics technology can achieve reproducible high shear forces to control particle size which gives polymer nanoparticles produced the ability to terminally sterilize via filtration and also control the release of the ingredients. 

Our Approach

Microfluidizer® processors are designed to be simple to use and clean with the option of conforming to cGMP requirements. 
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In detail

Polymer Nanoparticles

The Benefits of biodegradable polymer nanoparticles include their ability to:

  • Deliver a combination of various therapeutic ingredients
  • Include targeting moieties
  • Protect active ingredients from degradation
  • Control the release of ingredients
  • Terminally sterilize through filtration

Listen to Dhruba J. Bharali, Ph.D discuss the process development for the manufacture of nanotetrac

WEBINAR Listen to the webinar where Dhruba J Bharali Ph.D discusses manufacture of nanotetrac for pharmaceutical applications > click here

Key Steps in the process of Polymer Nanoparticle Development:

Determine Formulation:

  • Water phase: water + surfactant
  • Oil phase: water immiscible solvent + polymer + other ingredients (such as actives, contrast agents, etc.)

Factors to be considered:

  • Water miscibility
  • Boiling point
  • Toxicity
  • Active Pharmaceutical Ingredients (APIs)
  • Diagnostic ingredients (such as contrast enhancers)
  • Other ingredients (such as para-magnetic particles, metal oxides, etc.)

Key Steps in the process of Polymer Nanoparticle Development:

Determine Process

  • Add oil to the water phase
  • Mix using a rotor-stator motor to create a stable pre-mix
  • Process the pre-mix using a Microfluidizer® homogenizer after considering the critical processing parameters: chamber type, processing pressure, temperature and number of passes

Solvent Extraction

Solvent can be extracted from the formulation in several ways:

  • Allow the solvent to evaporate in a hood while mixing
  • Use a solvent-exchange technique, such as a separator funnel or rotary-evaporator

Microfluidizer® Processor Results

Particle size analysis is often used to evaluate polymer nanoparticles. Utilizing specific analytical techniques, including dynamic light scattering, optical microscopy, and SEM or TEM, we have found that Microfluidizer® technology is able to reduce polymer droplet size significantly after several passes.

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Watch our webinar on Microfluidizer: A Tool for Process Development to Manufacture Nanotetrac

Resources

Webinar

Microfluidizer: A Tool for Process Development to Manufacture Nanotetrac

WEBINAR Listen to the webinar where Dhruba J Bharali Ph.D discusses manufacture of nanotetrac for pharmaceutical applications > click here
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Microfluidics International Corporation, the manufacturer of Microfluidizer® high shear fluid processors, is a leader in the design and production of laboratory and commercial processing equipment used in the production of micro- and nano-scale materials for pharmaceutical, biotech, chemical and diverse industries. 

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