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      APPLICATIONS

      Polymer Nanoparticles

      Ideal Technology for Producing Polymer Nanoparticles

      Polymer nanoparticles represent one of the most innovative drug delivery systems due to their ability to deliver a wide variety of drugs and improve efficacy. Initially formulated like emulsions, a very small droplet consisting of a solvent containing both the polymer and drug of choice is formed. Once the solvent is evaporated, the polymer hardens and encapsulates the drug leaving very small, solid particles.

      EXPLORE:

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      YOUR CHALLENGES

      Polymer Nanoparticle Formulations

      Useful in targeted delivery of drug molecules to improve therapeutic efficacy, it is important to be able to control the manufacturing process. Once R&D formulations have been met, repeatable consistent scaleup is essential for larger commercialization volumes.

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      HOW WE CAN HELP

      Reproducible Polymer Nanoparticle Manufacturing

      Our technology achieves reproducible high shear forces to control particle size giving polymer nanoparticles the ability to be terminally sterilized via filtration and controlled release.

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      OUR APPROACH

      Scalable and Simple to Use Technology

      Microfluidizer® processors are designed to be simple to use and clean with the option of conforming to cGMP requirements.

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      OUR EXPERIENCE

      Technology for Polymer Nanoparticle Formulations

      Our 40 years of application development and machine engineering provide the experience to help drive your product to market as quickly as possible.

      ADVANTAGES

      Benefits of Polymer Nanoparticle Development

      Biodegradable polymer nanoparticles are an innovative drug delivery system, offering a number of benefits:

      • Delivery of a combination of various therapeutic ingredients
      • Ability to include targeting moieties
      • Protecting active ingredients from degradation to ensure efficacy
      • Control of the release of ingredients
      • Particles small enough to be sterilized through filtration

      Listen to Dhruba J. Bharali, Ph.D discuss the process development for the manufacture of nanotetrac.

      Watch the Webinar
      CONTACT US

      Do You Need Support With Your Next Steps?

      Microfluidics' scalable and simple to use technology offers an ideal solution for polymer nanoparticle formulation. Let our team of experts guide you through your options.
      FORMULATION

      Formulating Polymer Nanoparticles

      Key steps in the formulation of Polymer Nanoparticles:

      • Aqueous phase: the water and surfactant are combined.
      • Oil phase: the polymeric and other hydrophobic ingredients (such as actives, contrast agents, etc.) are dissolved in the water immiscible solvent.

      Factors to be considered in selecting the solvent:

      • Water miscibility
      • Boiling point
      • Toxicity
      • Active Pharmaceutical Ingredients (APIs)
      • Diagnostic ingredients (such as contrast enhancers)
      • Other ingredients (such as para-magnetic particles, metal oxides, etc.)
      RESOURCE

      Microfluidizer® Technology for the Development of Polymer Nanoparticles

      This application note explains some key formulation considerations when developing water-in-oil (W/O) emulsion evaporation processes as well as a step-by-step guide for creating polymer nanoparticles using Microfluidizer® processors.

      Download the App Note
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      EXTRACTION

      Extracting Polymer Nanoparticles

      Processing steps:

      • Prepare the separate oil & aqueous phases
      • Add oil to the water phase
      • Using a rotor-stator motor, create a coarse emulsion as a stable pre-mix.
      • Process the pre-mix using a Microfluidizer® high shear homogenizer. In selecting the model, consider the critical processing parameters of chamber type, processing pressure, temperature and number of passes.

      Solvent Extraction process:

      • Allow the solvent to evaporate in a hood while mixing

      OR

      • Use a solvent-exchange technique, such as a separator funnel or rotary-evaporator

      By working together with your formulation expertise, our engineers find the optimal solution in meeting your product goals. Our experienced process and application engineers accelerate nanomaterials development, improve production efficiency, and train and educate personnel.

      With a worldwide reputation and proven track record in creating best-in-class nanoemulsions, our dedicated and talented team has the expertise to help you achieve your target particle size and distribution curve.

      RESULTS

      Polymer Nanoparticle Examples

      Microfluidizer® technology produces on-target particles. Particle size analysis is often used to evaluate polymer nanoparticles.

      Utilizing specific analytical techniques, including dynamic light scattering, optical microscopy, and SEM or TEM, we have found that Microfluidizer® technology is able to reduce polymer droplet size significantly after several passes.

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      BLOG ARTICLES

      Expert Advice and Information

      Recommended downloads for manufacturers looking to achieve on-target particle sizes for polymer nanoparticles.

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