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M815 Microfluidizer® Processor

For Small & Pilot Scale Production Batches

Bridging the gap between the lab and production the M815 processor enables users to replicate operating conditions as each batch scales up.

Like all Microfluidizer® processors, the M815 utilizes the fixed-geometry Interaction Chamber and constant pressure pumping system which enables users to achieve small particle sizes with uniform, tight particle size distribution with scale-up guaranteed.

The M815 models are designed to span the gap between the lab scale (M110P) and production scale (M700 series) models. It achieves product flow rates to 1.0-1.2l/min up to 2068 bar (30,000 psi).

This technology enables easy monitoring of key process parameters and facilitates the safe processing of thermally sensitive materials. As a self-contained unit, mounted on locking casters for portability, it features accessible maintenance points for easy upkeep.

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M815 Microfluidizer® Processor


Standard Features

  • Product feed pump, with pressure gauge & purge valve
  • Heat exchanger
  • Diamond Interaction Chamber™
  • Ceramic Auxiliary Processing Module™ (APM™)
  • Ceramic (Zirconia) plunger with seal quench for extended seal life
  • Stainless steel enclosure
  • Gauges for measuring hydraulic drive pressure, hydraulic oil level and temperature
  • Mounted on locking casters for portability, standard door width
  • Maximum feed temperature range of 70˚C (158˚F)

Optional Features

  • Motor starter panel
  • RTD temperature sensors
  • Sanitary flush diaphragm pressure transducer with digital readout
  • Product inlet strainer
  • IQ/OQ documentation & execution

Pharma and Biotech

Options are available for pilot batch processing to meet the needs of pharmaceutical and biotechnology customers. A range of options are available to suit specific requirements.

The M815 can be designed to achieve cGMP standards which is vital for applications such as: vaccine adjuvants and sterile nanoemulsions. Each machine comes equipped with a standard with a feed pump and heat exchanger, which makes it easy to use simply by attaching the feed vessel and collection vessel then it's ready to run.



Basic Biopharma:

  • cGMP as specified by the American Society for Mechanical Engineers – Material Certificates for all product contact parts included in an electronic Turnover Package (TOP)
  • Surface Finish – Electropolished and passivated - surface finish of < 20 Ra 
  • USP Class VI elastomers
  • Drainability – A sanitary heat exchanger, a sanitary flush pressure transducer and pitched piping are included to ensure all equipment can be drained effectively.
  • CIP - clean in place

Enhanced Biopharma:

  • Includes all of the features of the Basic Biopharma plus:
  • 21 CFR Part 11 Data Acquisition
  • Industrial Personal Computer (IPC)
  • Other options include - automation, conductivity sensors & mass flow meter

Aseptic Biopharma:

  • All of the Enhanced Biopharma features plus:
  • Steam in Place (SIP) for processing in a sterile environment
  • Equipment is fully automated
  • Also recipes for Steam, Prime, Run & Drain

The M815 processor is recommended for the following applications:

  • Nanoemulsions (with and without API)
  • Nanodispersions
  • Microencapsulation
  • Deagglomeration
  • Cell Disruption
M815 Microfluidizer® Processor


The Specifications for the M815 Pilot Scale Microfluidizer® Processor Include:

  • Operating pressure of up to 30,000 psi/2068 bar
  • Minimum sample size - 1.5 l
  • Flow rate - up to 1.0 - 1.2 l/min
  • Power - 60 hz / 460 V 3 phase
  • Noise - 80 dB TWA

Our Range of High-Pressure Lab,
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M815 Microfluidizer® Processor


Yes! By processing under the same conditions (such as the Interaction Chamber™, pressure and number of passes) the exact results will be achieved whether it’s processed on a lab scale, pilot scale or production scale model. Learn more about our scale up test performed by our Application Lab Team

Our Aftermarket Team is available to help you place your order and will advise you on the critical parts and spares you should keep on hand to avoid interuptions.

Microfluidizer® technology achieves nanoscale, uniform particles which are critical for absorption, content uniformity and shelf-life in drug delivery.

Microfluidics differentiates itself from its competition because of its unparalleled ability to achieve superior, repeatable results with seamless, linear scale up capabilities.

Learn more