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MP350 Microlyser™ Processor

A Production Scale Technology for Cell Disruption

The MP350 Microlyser™ processor is an innovation in maximizing high yields in cell disruption on the production scale. 

The MP350 Microlyser™ is an effective solution for the cell disruption application. Utilizing a hybrid approach which incorporates Microfluidics proprietary Interaction Chamber technology, with a unique sanitary, electric pumping system, the MP350 Microlyser delivers superior cell disruption yields. The MP350 Microlyser has the same multi-slotted fixed-geometry Interaction Chambers that all Microfluidics equipment possess. This technology ensures that 100% of the material undergoes identical conditions and guarantees repeatable results batch-to-batch at production volumes.

Our new, unique approach provides industry-leading pressure up to 30,000 PSI (2068 bar). This hybrid solution maximizes protein yields and ensures high product quality in cell disruption of various cells. From E. coli to difficult yeast cells, which require higher shear, our MP350 Microlyser is an ideal cell disruption solution.

Designed specifically for biotech applications and engineered with full cGMP compliance in mind, our precision-designed/manufactured machine readily achieves high-yield cell disruption results.

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Biotech Innovation award (2)-1


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MP350 Microlyser™


Standard Features

  • Multi-slotted Diamond Interaction Chamber™
  • High Pressure Processing up to 30,000 PSI (up to 2068 bar)
  • Unique Sanitary, Electric Pumping System for Biopharma
  • Steam in Place (SIP) and Clean in Place (CIP) feature to meet Biopharma standards.
  • Pharma Grade Process Piping
MP350 Microlyser™


The specifications of the MP350 Microlyser™:

  • Pressure Range - Up to 2068 bar (up to 30,000 PSI)
  • Flowrate - Up to 300 lph @ 2068 bar (5.0-5.2 lpm/300 lph)
  • Feed Temperature (Max) - 70°C / 158°F
  • Dimensions (L x W x H) - 73” x 37” x 71” (185 cm x 95 cm x 180 cm)
  • Weight - 1800 kg / 3970 lbs

Utility Requirements

  • Cooling water for lubrication:
    10 LPM Water at 5-10oC (2.64 GPM Water at 41-50oF)
  • Pharmaceutical grade feed pump: Air operated double diaphragm for feed pressure:
    0.4 µm (16Ra) surface finish, requires 0.85m3/min @ 6.9 bar (30 SCFM @ 100 psi) minimum, -37oC to –18oC (-35oF to 0oF) dew point.
  • SIP Requirement:
    Require saturated clean steam supply: at 130oC & 145oC temperature @ 22.6 kg/hr. @ 2.4 bar (50 lbs./hr. @ 35 psi)
MP350 Microlyser™


The unique technology of the MP350 Microlyser™ makes it a preferred choice over its competition due to its ability to obtain:

  • Consistent Shear Rates with Fewer Passes 
  • Controlled Temperature Regulation 
  • Efficient Separation 
  • Ease of Cleaning 
  • Repeatable Results 

The MP350 Microlyser™ is a perfect solution for superior cell disruption results on a production scale. This hybrid technology incorporates Microfluidics propriety Interaction Chamber™ with a patented sanitary electric pumping system to achieve high yields and improved product quality. 

The Microlyser™ technology incorporates Microfluidics' revolutionary Interaction Chamber™ technology with a sanitary, electric pumping system with consistent pressure for repeatable, reliable results. 

With Microfluidics' proprietary Interaction Chamber™ technology, all material receives the same conditions and thereby guarantees identical results batch-to-batch.