Nanoparticle Albumin Bound (nab) drug delivery technology

Microfluidizer® Technology for creating effective drug delivery systems for Nab-paclitaxel.

With fewer side-effects than traditional systems, nanoparticle albumin bound (Nab) drug delivery is used for delivering chemotherapy medication by combining two immiscible substances, albumin (an aqueous protein) with a solvent-based agent. Achieving small and uniform particle size is a key step in making this critically important targeted drug delivery method.


Technology for Nanoparticle Albumin Bound (nab) drug delivery.

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Your Challenges

Nab-paclitaxel drug delivery

Solvent-based paclitaxel causes side effects for patients.

Achieving small & uniform particle size is a key step in making nanoparticle albumin-bound (nab) drug delivery systems.

Creating the right manufacturing process that enables downstream processes to be more effective & ensuring the final product meets target physiochemical properties can be difficult to achieve if the wrong technology is applied.

How We Can Help

Nanoparticle Albumin Bound (nab) drug delivery

Using human protein albumin drug delivery reduces side effects but it can be difficult to create. Microfluidizer® technology delivers precisely controlled high shear forces creating nanoparticles at the target size and distribution.

Our processors produce best-in-class stable nanoemulsions offering an effective drug delivery system for nab paclitaxel.

The process is linearly scalable from the lab to production.

Our Experience

Technology for Creating Stable Nanoemulsions

Our technology is widely used for creating stable nanoemulsions that can be sterile filtered – ideal when producing nab PTX/PXT.

Our Approach

Scalable manufacturing

We work with our customers to achieve the target particle size and distribution they need in their process and help them to scale up production.

for Nanoemulsions

Request your free no-obligation consultation. Let us help you solve your nanoemulsion challenges.
In Detail

Nanoparticle Albumin Bound (nab) paclitaxel drug delivery

Effective drug delivery system for nab paclitaxel.

Nanoparticle Albumin Bound (nab) drug delivery is a critically important method for delivering chemotherapy medication.

Nanoparticle albumin bound (nab) technology is one of the most attractive delivery platforms, especially for some of the hard-to-deliver low aqueous solubility and high toxicity therapeutic agents such as chemotherapeutics.

One well known example is nab-paclitaxel, which was the first FDA approved, highly successful, chemotherapy drug which uses the nanoparticle albumin-bound method of drug delivery.

Nab-paclitaxel is used in the treatment of advanced and spreading pancreatic cancers, metastatic breast cancers and non-small lung cancers.

download the application note on how to manufacture nanoparticle albumin bound (nab) paclitaxel


It is formulated by encapsulating the paclitaxel molecule inside the naturally occurring human protein albumin.  This avoids the traditional use of solvent-based products which contributed to more severe patient side-effects.

The challenge is combining the paclitaxel and albumin and converting them into a suitable form for administering to patients.  Simply mixing the two together doesn’t work.  They need to be combined as a nanoemulsion.

See the Techniques tab to find out more.


How to create nanoparticle albumin bound paclitaxel.

Formulating nab paclitaxel as a nanoemulsion is a superior methodology that ensures the paclitaxel and albumin are combined correctly.

The active ingredient, which is the paclitaxel, is dissolved in an organic solvent to form an oil phase. This is then mixed with an aqueous phase – which is the albumin solution.  This produces a coarse emulsion which is then processed using high shear to create a nanoemulsion.

This high shear is delivered via Microfluidizer® technology, which produces the target droplet size with a mean particle size of 130 nanometers and a tight distribution.

The resulting nanoemulsion undergoes further processing to remove any traces of the organic solvent, it is then submitted to sterilization and lyophilization steps to create the final product in the form of powder.

We would recommend the M110P is used in lab-scale studies.  When scale up is required, we would advise using the 7250 Enhanced model which will produce the same results as seen in the lab, but in liters of volume.

M110P and 7250 Microfluidizer models


Benefits of Microfluidizer® technology

Microfluidizer® processors are ideal for manufacturing nanoemulsions that reach the target particle size with a tight particle size distribution.  The Microfluidizers® processors are designed to clean and operate easily.

Microfluidizer® technology delivers the highest shear force uniformly to ensure every batch achieves the same stable, tight particle size result.  

Our revolutionary Interaction Chamber™ system provides scalability so results can be repeated regardless of volume.  This technology ensures the same quality from lab to pilot scale to manufacturing.

Interaction Chamber

Microfluidizer® processors are:

  • Easy to operate
  • Reliable to use
  • Low cost to maintain
  • Compliant with cGMP regulations
  • Linearly scalable from 2ml to Liters per hour

Our engineers, by working together with your formulation expertise, find the optimal solution in meeting your product goals.
Our experienced process and application engineers accelerate nanomaterials development, improve production efficiency, and train and educate personnel.
With a worldwide reputation and proven track record in creating best-in-class nanoemulsions, our dedicated and talented team has the expertise to help you achieve your target particle size and distribution curve.

download the application note on how to manufacture nanoparticle albumin bound (nab) paclitaxel

Microfluidizer® technology has been proven time after time.

The manufacturing process is easily scaled up. Tests that can be run in the R&D lab using the M110P model can directly be scaled up to the M7250 Enhanced production-scale machine.

Microfluidizer® technology outperforms conventional high-pressure homogenizers (HPH).  The nanoemulsions created have tighter particle distributions and are more efficient in processing.

Creating a stable nanoemulsion ensures the Nanoparticle Albumin Bound (nab) drug delivery works effectively in delivering the paclitaxel drug to the patient.

Nab Paclitaxel Image


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Resources & Guides

Nanoparticle Albumin-Bound Resources

Recommended downloads for nanoparticle albumin-bound paclitaxel.