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Liposomes

Microfluidizer® Technology for Successfully Processing Liposomes.

A liposome is a spherical lipid vesicle with a bi-layered membrane structure and is considered one of the most efficient drug delivery systems for administering nutrients and pharmaceutical drugs. Liposome drug delivery is unique because of its ability to encapsulate and deliver active ingredients to targeted areas.

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Find out how our technology effectively manufactures liposomes.

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Liposomes Production

Your Challenges

Liposome production

There are various ways to produce liposomes however it is an industry challenge to produce solvent independent, scalable, high-quality liposomes that contain high levels of therapeutic agents.

How We Can Help

Liposomes Manufacturing Technology

Microfluidizer® technology has a very fast reduction of liposome vesicles with guaranteed scalability even with high concentrations therapeutic levels.

Our Experience

Scalable Liposomes Production

Let us use our collective 90 years of applications development and machine engineering experience to help drive your product to market as quickly as possible.

Our Approach

Solutions for Liposomal Formulation

Microfluidizer® processors are designed to be simple to use and clean with the option of conforming to cGMP requirements.

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In Detail

Microfluidizer® Processor Solutions for Liposomal Formulation

Microfluidizer® technology to generate scalable, high quality liposomes.

Liposome Drug Delivery Applications.

Liposomes, small spherical lipid vesicles with a bi-layered membrane, are widely utilized in pharmaceutical formulations to:

  • Encapsulate both hydrophilic and hydrophobic therapeutic agents with high efficiency
  • Protect the encapsulated drugs from undesirable effects from external conditions
  • Functionalize certain ligands that target specific cells, tissues, and organs of interest
  • Be coated with inert and biocompatible polymers such as polyethylene glycol (PEG), prolonging the liposome circulation half-life in vivo
  • Develop nanoparticle liposomal formulations with the desired composition, size, surface charge, and other properties
  • Generate next-generation Vaccine Adjuvant Production

 

Technology for Liposome Production Download the App note

Liposome drug delivery applications include treatment for fungal and protozoan infections, influenza, Hepatitis A, malignant lymphomatous meningitis, breast cancer, age-related macular degeneration and more. Clinical trials are under way to test the effectiveness of liposomes to deliver drugs used in the treatment of leukemia, soft-tissue sarcoma, ovarian cancer and Non-Hodgkin lymphoma.

Liposomes have also been developed both as the vaccine delivery systems and the adjuvant such as adjuvant systems 01 (AS01) used in the malaria and shingles vaccines.

Professor Perrie from the University of Strathclyde, UK has been conducting extensive research in Drug Delivery.  Watch the webinar to hear more:

WEBINAR Listen to the webinar on formulating liposomes & the importance of vesicle size control. > click here

The Microfluidizer® Technology Solutions for Liposomal Formulation

The Microfluidizer® processor offers an ideal solution for the production of liposomal formulations due to the following advantages:

  • Continuous process
  • Guaranteed scalability using Interaction Chamber™ technology
  • Optimal temperature control
  • Samples are processed at a constant shear rate
  • Highest shear rate capability of any homogenizer

Discover how to efficiently  create production scale liposomes

The Microfluidizer Equipment Results.

Microfluidics engineers helped a biotech research company successfully process liposomes using Microfluidizer® equipment. The average particle size was reduced from 394.8 nm to 132.6 nm after one pass, and from 394.8 nm to 107.7 nm after two passes.

Read the report here

Our experts also helped a pharmaceutical customer develop various formulations of a small molecule API liposome for IV drug delivery in the treatment of cancer. Microfluidizer® technology was very successful in creating several liposomal formulations with the target particle size distributions — on both the lab and production scales.

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Resources & Guides

Liposomes Resources

Recommended downloads for manufacturing liposomes.

Featured Resources

Liposomes Application Notes
Application Notes
Microfluidizer® Technology for Liposome Production.
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Application Notes
Microfluidizer® Technology for solvent-free production of liposomes.
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Microfluidizer® Technology for solvent-free production of liposomes
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September 8 2022
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Liposomes Related Resources

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Microfluidics International Corporation, the manufacturer of Microfluidizer® high shear fluid processors, is a leader in the design and production of laboratory and commercial processing equipment used in the production of micro- and nano-scale materials for pharmaceutical, biotech, chemical and diverse industries. 

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