for Liposomes

Microfluidizer® Successfully Processes Liposomes

Your Challenges

There are a various ways to produce liposomes however it is an industry challenge to produce solvent independent, scalable, high quality liposomes that contain high levels of therapeutic agents.

Our Experience

Let us use our collective 90 years of applications development and machine engineering experience to help drive your product to market as quickly as possible.

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How we can help

Microfluidics technology has very fast reduction of liposome vesicles with guaranteed scalability even with high concentrations therapeutic levels. 

Our Approach

Microfluidizer® processors are designed to be simple to use and clean with the option of conforming to cGMP requirements. 

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In detail

Liposomes

Liposome Drug Delivery Applications

Liposomes, small spherical lipid vesicles with a bi-layered membrane, are widely utilized in pharmaceutical formulations to:

  • Encapsulate both hydrophilic and hydrophobic therapeutic agents with high efficiency
  • Protect the encapsulated drugs from undesirable effects from external conditions
  • Functionalize certain ligands that target specific cells, tissues and organs of interest
  • Be coated with inert and biocompatible polymers such as polyethylene glycol (PEG), prolonging the liposome circulation half-life in vivo
  • Develop nanoparticle liposomal formulations with the desired composition, size, surface charge and other properties
  • Generate next-generation vaccine adjuvants

Liposome drug delivery applications include treatment for fungal and protozoan infections, influenza, Hepatitis A, malignant lymphomatous meningitis, breast cancer, age-related macular degeneration and more. Clinical trials are under way to test the effectiveness of liposomes to deliver drugs used in the treatment of leukemia, soft-tissue sarcoma, ovarian cancer and Non-Hodgkin lymphoma.

The Microfluidizer Process Solutions for Liposomal Formulation

The Microfluidizer® processor offers an ideal solution for the production of liposomal formulations due to the following advantages:

  • Continuous process
  • Guaranteed scalability using Microfluidizer® interaction chamber technology
  • Optimal temperature control
  • Samples are processed at a constant shear rate
  • Highest shear rate capability of any homogenizer

The Microfluidizer Equipment Results

Microfluidics engineers helped a biotech research company successfully process liposomes using Microfluidizer® equipment. The average particle size was reduced from 394.8 nm to 132.6 nm after one pass, and from 394.8 nm to 107.7 nm after two passes.

Our experts also helped a pharmaceutical customer develop various formulations of a small molecule API liposome for IV drug delivery in the treatment of cancer. Microfluidizer® technology was very successful in creating several liposomal formulations with the target particle size distributions — on both the lab and production scales.

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Front cover liposomes lab report

Resources

Lab Report

Liposomes report for biotech research company - To produce DNA encapsulated liposomes with an average particle size between 50 and 100 nanometers.

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