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Microfluidizer® Technology for Successfully Processing Liposomes

A liposome is a spherical lipid vesicle with a bi-layered membrane structure and is considered one of the most efficient drug delivery systems for administering nutrients and pharmaceutical drugs. Liposome (and lipoplex) drug delivery is unique because of its ability to encapsulate and deliver active ingredients to targeted areas.


Liposome Production

There are various ways to produce liposomes however it is an industry challenge to produce solvent independent, scalable, high-quality liposomes that contain high levels of therapeutic agents.


Liposomes Manufacturing Technology

Microfluidizer® technology has a very fast reduction of liposome vesicles with guaranteed scalability even with high concentrations therapeutic levels.


Solutions for Liposomal Formulation

Microfluidizer® processors are designed to be simple to use and clean with the option of conforming to cGMP requirements.


Scalable Liposomes Production

Let us use our decades of application development and machine engineering experience to help drive your product to market as quickly as possible.


Liposome Drug Delivery Applications

Liposomes, small spherical lipid vesicles with a bi-layered membrane, are widely utilized in pharmaceutical formulations to:

  • Encapsulate both hydrophilic and hydrophobic therapeutic agents with high efficiency
  • Protect the encapsulated drugs from undesirable effects from external conditions
  • Functionalize certain ligands that target specific cells, tissues, and organs of interest
  • Be coated with inert and biocompatible polymers such as polyethylene glycol (PEG), prolonging the liposome circulation half-life in vivo
  • Develop nanoparticle liposomal formulations with the desired composition, size, surface charge, and other properties
  • Generate next-generation Vaccine Adjuvant Production

Liposome drug delivery applications include treatment for fungal and protozoan infections, influenza, Hepatitis A, malignant lymphomatous meningitis, breast cancer, age-related macular degeneration and more. Clinical trials are under way to test the effectiveness of liposomes to deliver drugs used in the treatment of leukemia, soft-tissue sarcoma, ovarian cancer and Non-Hodgkin lymphoma.

Liposomes have also been developed both as the vaccine delivery systems and the adjuvant such as adjuvant systems 01 (AS01) used in the malaria and shingles vaccines.

Professor Perrie from the University of Strathclyde, UK has been conducting extensive research in Drug Delivery. Watch the webinar on 'formulating liposomes and the importance of vesicle control' to hear more.

Watch the Webinar

Solutions for Liposomal Formulation

The Microfluidizer® processor offers an ideal solution for the production of liposomal formulations due to the following advantages:

  • Continuous process
  • Guaranteed scalability using Interaction Chamber™ technology
  • Optimal temperature control
  • Samples are processed at a constant shear rate
  • Highest shear rate capability of any homogenizer

For more information, view our application note on creating production scale liposomes.

Download the App Note


Microfluidizer® Technology for Liposome Production

Whilst many methods exist to make liposomes in small quantities, only a few methods are realistic for production scale manufacturing. In this Application Note we look at how Microfluidizer® Technology plays a vital role in the production of liposomes.

Download the App Note

Microfluidizer® Processor Equipment Results

Microfluidics engineers helped a biotech research company successfully process liposomes using Microfluidizer® equipment. The average particle size was reduced from 394.8 nm to 132.6 nm after one pass, and from 394.8 nm to 107.7 nm after two passes.

Our experts also helped a pharmaceutical customer develop various formulations of a small molecule API liposome for IV drug delivery in the treatment of cancer. Microfluidizer® technology was very successful in creating several liposomal formulations with the target particle size distributions — on both the lab and production scales.


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