M110EH Microfluidizer®An electric-hydraulic pilot scale homogenizer

for continuous, High Shear Fluid Processing in small volumes

The M110EH is ideal for pilot scale batch processing.  Think of it as a miniature version of the M700 production series. 

With the same fixed-geometry Interaction ChamberTM technology as all the other Microfluidics models, the M110EH produces fully comparable results to those achieved in the lab.  Rest-assured that the results achieved at this pilot scale can be guaranteed to fully scale up to production volumes on the M700 series.

M-110EH Microfluidizer electric-hydraulic pilot scale homogenizer

The M110EH contains an on-board 3.7 kW (5 HP) electric-hydraulic drive that powers a single acting intensifier pump, all mounted on casters for mobility.  It is ideally positioned for pilot scale work being able to handle sample sizes as small as 120 mL up to batches of 100 Liters.

Pressure from 2,500 to 30,000 psi is possible from the single-acting intensifier pump which amplifies the hydraulic pressure to the appropriate level. The desired pressure is selected by a simple turn of a knob, and supplied at a constant rate to the product stream. By maximizing energy-per-unit fluid volume, this machine produces uniform sub-micron particle and droplet sizes.

When the product exits the Interaction ChamberTM, it flows through the on-board heat exchanger which regulates the product to a desired temperature ensuring a consistent discharge temperature. At this point, the product is recirculated through the system for further processing or directed externally to the next step in the process.

Download the M110EH brochure

Available For

Pharma and Biotech

cgmp compliant pilot scale equipment

Pharma & Biotech options are available for pilot batch processing - with a range of options available to suit specific requirements.

Designed to achieve cGMP standards, there are a range of models to suit the standard Biopharma needs, moving on to the Enhanced Biopharma model and on to the Aseptic Biopharmaceutical model. These options are critical when scaling up from the lab to pilot batches in typical applications such as making vaccine adjuvants and creating sterile nanoemulsions.

Basic Biopharma:

  • cGMP as specified by the American Society for Mechanical Engineers
  • Traceability – Material Certificates for all product contact parts included in an electronic Turnover Package (TOP)
  • Surface Finish – Electropolished and passivated - surface finish of < 20 Ra 
  • USP Class VI elastomers
  • Drainability – A sanitary heat exchanger, a sanitary flush pressure transducer and pitched piping are included to ensure all equipment can be drained effectively
  • IQ/OQ Documentation
  • CIP - clean in place

Enhanced Biopharma:

  • includes all of the above features plus 21 CFR Part 11 Data Acquisition
  • Industrial Personal Computer (IPC)
  • other options include - automation, conductivity sensors & mass flow meter

Aseptic Biopharma:

  • all of the above features plus Steam in Place (SIP) for processing in a sterile environment
  • equipment is fully automated
  • also recipes for Steam, Prime, Run & Drain

Aseptic Biopharma model:

M110EH-Basic-Biopharma-Model
 

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In detail

M110EH pilot scale homogenizer

The M110EH pilot scale high shear liquid processor

The M110EH pilot scale model has a range of optional features to suit individual needs:

Standard Features:

  • Patented, wear-resistant diamond interaction chamber — no moving parts

  • Ceramic Auxiliary Processing Module (APM)

  • Ceramic (Zirconia) plunger for extended seal life

  • Stainless steel enclosure

  • Electric hydraulic power unit

  • Gauges for measuring process pressure, hydraulic drive pressure, and hydraulic oil level and temperature

  • Portable self-contained unit, mounted on locking casters

  • Feed temperature range 16˚C – 75˚C (35˚F – 165˚F)

  • TEFC (totally enclosed fan-cooled) motor, starter, controls and power cord

Optional Features:

  • 2 liter reservoir

  • 2 liter pressure-type reservoir

  • 2 gallon pressure-type feed tank

  • Sanitary flush diaphragm pressure transducer with digital readout

  • On-board air compressor for air switch activation

  • Interaction chamber cooling bath

The specifications of the M110EH pilot scale Microfluidizer®:

  • Operating pressure of up to 30,000 psi/2068 bar

  • Minimum sample size - 100 mL

  • Flow rate - up to 295 - 450 mL/min

  • Power - 60 hz / 460 V 3 phase

  • Noise - 80 dB TWA

  • Requires a small volume of compressed air and cooling water supplies

M110EH-details

 

The pilot-scale M110EH is recommended for a variety of applications:

  • Particle Size Reduction for Submicron and Nano-Sized Particles
  • Deagglomeration
  • Cell Disruption
  • Immiscible Liquid Emulsions
  • Solid-in-Liquid Suspensions
  • Liposomes

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