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M110EH Microfluidizer® Processor

Pilot Scale Homogenizer for Continuous Processing

The M110EH is ideal for pilot scale batch processing. Think of it as a miniature version of the M700 production series. 

With Microfluidics' fixed-geometry Interaction Chamber technology, the M110EH produces fully comparable results to those achieved in the lab. The results achieved at this pilot scale are guaranteed to full M700 series scale up production volumes.

The M110EH contains an on-board 3.7 kW (5 HP) electric-hydraulic drive that powers a single acting intensifier pump, all mounted on casters for mobility.  It is ideally positioned for pilot scale work being able to handle sample sizes as small as 120 mL up to batches of 100 Liters.

Pressure to 30,000 psi is possible from the single-acting intensifier pump which amplifies the hydraulic pressure to the appropriate level. The desired pressure is selected by a simple turn of a knob and supplied at a constant rate to the product stream. By maximizing energy-per-unit fluid volume, this machine produces uniform sub-micron particle and droplet sizes.

When the product exits the Interaction Chamber, it flows through the on-board heat exchanger which regulates the product to a desired temperature ensuring a consistent discharge temperature. At this point, the product is recirculated through the system for further processing or directed externally to the next step in the process.

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M110EH Microfluidizer® Processor


Standard Features

  • Wear-resistant Diamond Interaction Chamber™ — no moving parts
  • Ceramic Auxiliary Processing Module™ (APM™)
  • Ceramic (Zirconia) plunger for extended seal life
  • Stainless steel enclosure
  • Electric hydraulic power unit
  • Gauges for measuring process pressure, hydraulic drive pressure, and hydraulic oil level and temperature
  • Portable self-contained unit, mounted on locking casters
  • Stroke Counter

Optional Features

  • Larger stainless steel reservoirs
  • Pressure transducer and display
  • Product inlet & outlet thermocouple options
  • Feed Pump
  • Air compressor for air switch activation
  • Interaction Chamber™ cooling bath
M110EH Microfluidizer® Processor

Pharma and Biotech

Pharma & Biotech options are available for pilot batch processing - with a range of options available to suit specific requirements.

Designed to achieve cGMP standards, there are a range of models to suit the standard Biopharma needs, moving on to the Enhanced Biopharma model and on to the Aseptic Biopharmaceutical model. These options are critical when scaling up from the lab to pilot batches in applications such as: vaccine adjuvants,  nanoemulsions and cell disruption.

Basic Biopharma:

  • cGMP as specified by the American Society for Mechanical Engineers
  • Traceability – Material Certificates for all product contact parts included in an electronic Turnover Package (TOP)
  • Surface Finish – Electropolished and passivated - surface finish of < 20 Ra 
  • USP Class VI elastomers
  • Drainability – A sanitary heat exchanger, a sanitary flush pressure transducer and pitched piping are included to ensure all equipment can be drained effectively
  • CIP - clean in place

Enhanced Biopharma:

  • Includes all of the features of the Basic Biopharma plus:
  • 21 CFR Part 11 Data Acquisition
  • Industrial Personal Computer (IPC)
  • Other options include - automation and conductivity sensors 

Aseptic Biopharma:

  • Includes all of the features of the Enhanced Biopharma plus:
  • Steam in Place (SIP) for processing in a sterile environment
  • Also Recipes for Steam, Prime, Run & Drain
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The pilot-scale M110EH is recommended for a variety of applications:

Because the M110P offers flexibility in quantity size and delivers repeatable, scalable results, it is ideally used to create:

  • Particle Size Reduction for Submicron and Nano-Sized Particles
  • Cell Disruption
  • Deagglomeration
  • Immiscible Liquid Emulsions
  • Solid-in-Liquid Suspensions
  • Liposomes
CellDisruption-mehod-blog (1)
M110EH Microfluidizer® Processor


The M110EH Microfluidizer® Processor Specifications Include:

  • Operating pressure of up to 30,000 psi/2068 bar
  • Minimum sample size - 120 ml
  • Flow rate - up to 295-450 ml/min
  • Power - 60 hz/460 V 3 phase
  • Noise - 80 dB TWA
  • Requires a small volume of compressed air and cooling water supplies.

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M110EH Microfluidizer® Processor


Microfluidics’ laboratory application experts work diligently with customers to understand their application needs and advise on which processing conditions will yield the best results for their specific applications.

For drug and vaccine delivery, achieving narrow particle size and size distribution is critically important for filtration.

With seamless scale-up from lab to production, Microfluidizer® technology gets unparalleled results. Learn