Applications

Particle Size Reduction

Technology for achieving uniform target particle sizes on a Nano Scale.

Particle size reduction is the process in which large, solid particles are broken down into smaller particle sizes. This process is often achieved by the use of high shear forces. Particle size reduction is a key process used to transform bulky or randomly sized substances into uniform, small particles suitable for a wide range of applications. When done correctly, particle size reduction favorably alters certain key physiochemical properties of the raw material(s). The success of a given process, such as emulsions and suspensions, often depends on precise size reduction.

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Nanotechnology for particle size reduction

Nanotechnology options from microfluidics

Your Challenges

Uniform Particle Size Reduction

Throughout various industries, achieving a uniform particle size reduction without introducing contaminations can be one of the greatest challenges.

How We Can Help

Reproducible Results

Microfluidizer® technology utilizes constant pressure and fixed geometry Interaction ChamberTM to achieve reproducible uniform particle size with narrow distributions.

Our Experience

Nanotechnology Solutions

Let us use our collective 90 years of applications development and machine engineering experience to help drive your product to market as quickly as possible.

Our Approach

High Shear Processing

Microfluidizer® processors are designed to be simple to use and clean with the option of conforming to cGMP requirements. 

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In Detail

Particle Size Reduction

Microfluidizer® Particle Size Reduction Processors

Why do more than 1,700 leading companies in various industries prefer Microfluidics processing to other particle size reduction techniques? Microfluidizer® high shear fluid processors stand alone in their ability to achieve uniform target nanoparticle sizes. Our exclusive fixed-geometry Interaction Chamber™ exposes the product to consistent shear levels with repeatable results. When it comes to particle size reduction, Microfluidics provides important benefits.

How does a Microfluidizer Work?

 

Advantages of our Industry-Leading Size Reduction Machines.

Smallest Particle Sizes

With particle sizes typically 50% smaller than those produced by conventional homogenizers and other methods of particle size reduction, a Microfluidizer® processor enables you to achieve:

  • Improved bioavailability
  • Targeted drug delivery
  • Easier downstream processing

 

Narrowest Particle Size Distribution

Microfluidizer® technology allows you to achieve:

  • Stable products with prolonged shelf life
  • Optimized particle characteristics (e.g., gloss, reactivity)
  • Uniform product quality and temperature

Repeatable and consistent results

This benefit offers:

  • Guaranteed scale up from lab to pilot and production volumes
  • Precisely controlled particle sizes and characteristics


Improved Processing Efficiencies

Microfluidizer® processors provide:

  • Savings of time and money (few passes, easy to use and clean)
  • Effective cooling
  • Minimization or elimination of contamination (no media required)

Benefits of Controlled Particle Size Reduction.

Particle size affects numerous characteristics in the manufacture of pharmaceuticals, chemicals, food products and other materials, including:

  • Color - Uniform particle sizes assure color consistency from one batch to the next
  • Taste - More precise particle size reduction allows more consistent taste
  • Flowability - Critical to packaging, tableting, and weighing

 

  • Density - Reliable, repeatable particle size reduction techniques help control shipping costs and minimize dust
  • Chemical Reaction - Uniform, controlled chemical change

REPORT  Read how a dispersion of carbon in bleach  could be used as an ink jet ink  > Read now

Achieve Uniform Size Reduction

How does Microfluidizer® technology accomplish uniform submicron particle size reduction? The product is input into a reservoir that supports high solid content. A high-pressure pump generates forces up to 40,000 psi (2578 bar) to force the product stream into precisely engineered microchannels within the unique Interaction Chamber™. Because the Microfluidizer® technology has the ability to control shear rates, the smallest pressure required is typically used.

How does Microfluidizer® technology accomplish uniform submicron particle size reduction? The product is input into a reservoir that supports high solid content. A high-pressure pump generates forces up to 40,000 psi (2578 bar) to force the product stream into precisely engineered microchannels within the unique Interaction Chamber™. Because the Microfluidizer® technology has the ability to control shear rates, the smallest pressure required is typically used.

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Resources & Guides

Particle Size Reduction

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