Microfluidizer^® Technology
A Comparison of Cell Disruption Techniques

This Application Note provides an overview of the techniques used for cell disruption. It is important to achieve high rupture rates, but at the same time not to denature intracellular components by unnecessary elevation of temperature or excessive shear rates, which will adversely affect yield rates and protein activities.

The method applied should be easy to use, reliable, require little maintenance and be easy to clean.

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