Microfluidizer^® Technology for
Terminal Sterilization of Nanoemulsion Adjuvants

Nanoemulsions are promising vaccine adjuvants that improve tolerability and enhance immune response, especially when based on biodegradable oil-in-water systems. Because most adjuvanted vaccines are injected, sterilization is essential.

For formulations with heat-sensitive components, sterile filtration replaces heat sterilization, and its validation depends on a robust combination of process development and filtration technology.

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