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Liposomes are spherical lipid vesicles consisting of one or more bi-layered membrane structures. Phospholipids are most often used to form liposomes. Because of their structure - aqueous cores surrounded by lipid bi-layers - liposomes have the unique advantage (compared to other lipid based delivery systems) in that they can also encapsulate and deliver hydrophilic actives including nucleic acids.
In addition, liposomes can be formulated to enhance immunogenicity and serve as vaccine adjuvants.
Whilst many methods exist to make liposomes in small quantities, only a few methods are realistic for production scale manufacturing.
In this Application Note we look at how Microfluidizer® Technology plays a vital role in the production of liposomes.